3 the h3k27me3 demethylase utx is a putative tumor suppressor protein
Báo cáo khóa học: SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast docx
... (AR4) reporter strains by standard genetic methods High copy suppressor screen The Yep351-based yeast genomic library used for the suppressor screen was a gift from E Bogengruber (Institute for ... Braun, Melsungen, Germany) and total protein concentration was determined as described by Bradford [18] For b-galactosidase assays, an appropriate amount of protein was incubated in Z-buffer (5· ... was determined (A420) and activity of b-galactosidase (as U per mg protein) calculated as follows: DA420 · 1000/0.0045 · total protein (lg) · incubation time (min) For statistical analysis of sporulation...
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Báo cáo khoa học: The Drosophila jumonji gene encodes a JmjC-containing nuclear protein that is required for metamorphosis pot
... studies have clarified that JmjC-containing proteins act as histone demethylases [11] Lid, the closest protein to dJmj, was recently shown to be a histone demethylase that removes dimethyl and trimethyl ... that the JmjCcontaining proteins are histone demethylases and that the JmjC domain is responsible for their enzymatic activity [14–19] However, as several JmjC-containing proteins are predicted ... as histone demethylases because of the amino acid changes in the catalytic domain [11,12] Several other JmjC-containing proteins are considered to be enzymatically inactive as histone demethylases...
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Báo cáo khoa học: The leech product saratin is a potent inhibitor of platelet integrin a2b1 and von Willebrand factor binding to collagen pdf
... LAPP (an approximately 13 kDa leech antiplatelet protein isolated from Haementeria officinalis) and calin and saratin (approximately 65 kDa and 12 kDa proteins, respectively, both isolated from H ... predominantly acts via the Gq family of proteins [38], potentiated a2b1-independent platelet adhesion to soluble collagen only in the presence of the actions of the Gi protein- coupled agonist ADP This ... of saratin Physiologically, however, platelets are exposed to collagen in the presence of plasma proteins In order to investigate the ability of saratin to inhibit receptormediated interactions...
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The food you eat is a source of nutrients
... supplied by food sources Two types of Protein: Complete Proteins: • • Contain all essential amino acids They are found in animal sources Incomplete Proteins: Lack one or more of the essential ... Learning Zone Exp Proteins Food Sources: 10 Meat, fish,eggs, poultry, dairy products, legumes, nuts and seeds (Breads, cereals and vegetables also contain small amounts of protein. ) Function ... protein. ) Function in the Body: Provides energy Help to build, maintain, and repair body tissues Proteins are made up of chemical compounds called amino acids There are 20 amino acids ©2002 Learning...
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The food you eat is a source of nutrients
... supplied by food sources Two types of Protein: Complete Proteins: • • Contain all essential amino acids They are found in animal sources Incomplete Proteins: Lack one or more of the essential ... Learning Zone Exp Proteins Food Sources: 10 Meat, fish,eggs, poultry, dairy products, legumes, nuts and seeds (Breads, cereals and vegetables also contain small amounts of protein. ) Function ... protein. ) Function in the Body: Provides energy Help to build, maintain, and repair body tissues Proteins are made up of chemical compounds called amino acids There are 20 amino acids ©2002 Learning...
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Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development docx
... mammalian cortical granule proteins has been estimated to be between four and fourteen or more [10,19,20] Several specific proteins have been identified as cortical granule proteins [21] N-acetylglucosaminidase ... serum at 4°C with constant agitation for 90 minutes To remove any protein- A and Sepharose bead binding proteins before using ABL2, protein A-Sepharose beads were then added and incubated with the ... mouse blastocysts and which immunoprecipitates a 75-kDa protein from mouse oocytes, reacts immunocytochemically with cortical granules [20] The protein is released following in vitro fertilization...
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Báo cáo khoa học: The crystal structure of NlpI A prokaryotic tetratricopeptide repeat protein with a globular fold potx
... coefficient of a protein Protein Sci 4, 2411–2423 Kantardjieff KA & Rupp B (2003) Matthews coefficient probabilities: Improved estimates for unit cell contents of proteins, DNA and protein- nucleic ... AL, Kajander T, Pan W, Cocco MJ & Regan L (2004) Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins Protein Eng Des Sel 17, 399–409 Main ER, Jackson ... Barford D (1998) The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein protein interactions EMBO J 17, 1192–11199 15 Abe Y, Shodai T, Muto...
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Báo cáo khoa học: EspB from enterohaemorrhagic Escherichia coli is a natively partially folded protein pptx
... ‘natively unfolded’ proteins unstructred under physiologic conditions? Proteins 41, 415–427 42 Uversky VN (2002) Natively unfolded proteins: a point where biology waits for physics Protein Sci 11, ... that some proteins are unable to maintain well-defined structures, even under physiological conditions [39–44] These proteins are often called natively unfolded or intrinsically disordered proteins ... information and neural networks to predict protein secondary structure Proteins 19, 55–72 Rost B, Sander C & Schneider R (1994) PHD – an Automatic Mail Server for Protein Secondary Structure Prediction...
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Báo cáo khoa học: Common mode of DNA binding to cold shock domains Crystal structure of hexathymidine bound to the domain-swapped form of a major cold shock protein from Bacillus caldolyticus pot
... structure the two protein chains form a swapped dimer with two globular functional units which are composed of residues 1–35 from one protein chain and residues 38–65 from another protein chain (Figs ... DNA binding is dominated by stacking interactions between nucleobases and aromatic protein side chains for both proteins Based on this observation and on binding assays using a set of heptapyrimidines, ... amphipathic protein surface Several residues participating in ligand binding are located in regions designated as RNP motifs I and II, which can also be found in other RNA-binding proteins [26,27]...
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Báo cáo y học: "Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencin" ppt
... discovered for specific tumor types Many genes identified in our study are either known tumor suppressor genes (for example, BRCA1) or previously identified putative tumor suppressor genes (for ... association between LOH and tumor susceptibility is significant only when several tumor suppressor genes are involved in the LOH events [10,33] Second, in addition to common tumor suppressor genes shared ... cell surface proteins and five encoding extracellular matrix proteins Of the 16 cell surface proteins, seven are transmembrane receptors, including kinases in the FGFR family and G -protein coupled...
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Báo cáo y học: "Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein" doc
... molecular studies, the tetraspanin superfamily member proteins are cellular membrane proteins type III found on the cytoplasmic membrane [19] Such proteins play essential biological roles with distinctive ... (Fig.1a) One of the VP26 interacting proteins is a cellular membrane protein type III and is a homologue of tetraspanin family member cellular tetraspanin membrane protein (CTMP-7, GenBank accession ... tetraspanin-GFP fusion protein at 30 h post HSV-1 infection (Fig.2b) Evidence of VP26 interaction with CTMP-7 CTMP-7 molecules are present in purified HSV-1 virions Five proteins interacting with...
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Báo cáo khoa học: Metal ions modulate the folding and stability of the tumor suppressor protein S100A2 docx
... protein stability In S100A3, Zn2+ binding causes the loss of approximately 40% of the a-helical structure [13], supporting destabilization of the protein In contrast with S100A2, other S100 proteins, ... nuclear S100A2 and mutant proteins J Biol Chem 273, 18826–18834 18 Koch M, Diez J & Fritz G (2006) Purification and crystallization of the human EF-hand tumour suppressor protein S100A2 Acta Crystallogr ... binding to S100 proteins I Calcium- and zinc-binding properties of bovine brain S100 alpha alpha, S100a (alpha beta), and S100b (beta beta) protein: Zn2+ regulates Ca2+ binding on S100b protein J Biol...
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báo cáo khoa học: "RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression" doc
... Abnormalities of proto-oncogenes, such as RAS and MYC, or of tumor suppressor genes, such as mutations of the p53 gene, absence of RB protein, and homozygous deletions of the p16INK4a gene, have ... CD117 expression (Fig 4e) Conclusion These results build upon previous observations that a putative CML tumor suppressor gene is present at 1p36 that exhibits loss of heterozygosity during transformation ... Ben-Yehuda D, Schiller G, Landolfi R, Mizoguchi H, Koeffler HP: Chromosome band 1p36 contains a putative tumor suppressor gene important in the evolution of chronic myelocytic leukemia Blood 1998, 92:3405-3409...
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Identification of a new tumor suppressor pathway modulating rapamycin sensitivity in colorectal cancer
... inactivation of tumor suppressor genes in many cancers Thus, identification of these silencing tumor suppressor genes could provide insight into the biological processes and pathways underlying tumorigenesis ... epigenetic changes leading to inactivation of tumor suppressor genes in tumor progression 1.1.1 Genetic alterations as a cause of loss-of-function of tumor suppressor genes in cancer Cancer is essentially ... .1 1.1 Loss of tumor suppressor genes by genetic and epigenetic alterations in cancer 2 1.1.1 Genetic alterations as a cause of loss-of-function of tumor suppressor genes in...
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Designing a synthetic tumour suppressor protein
... soluble protein scaffold 20 A protein aptamer is able to bind to and specifically inhibit the protein- protein interaction of interest, allowing for characterization of a particular function of the protein ... target protein expression Small chemical compounds that bind specifically to the target protein can also be used to evaluate the effects of disrupting the target protein s interaction with other proteins ... validation 1.2 The protein aptamer approach to target validation The aptamer approach to target validation involves the development of miniproteins called protein aptamers Protein aptamers are...
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Báo cáo khoa học: The proapoptotic member of the Bcl-2 family Bcl-2 / E1B-19K-interacting protein 3 is a mediator of caspase-independent neuronal death in excitotoxicity pot
... mitochondrial membranes [13] Bcl-2 ⁄ E1B-19K-interacting protein (BNIP3) is a member of a unique subfamily of death-inducing mitochondrial proteins [14,15] BNIP3-induced cell death has been characterized ... 30 with a BNIP3– glutathione-S-transferase (GST) protein As shown in Fig 1E, immunoblotting for BNIP3 was completely blocked by the BNIP3–GST protein A nonspecific 62 kDa band was detected in ... Rockville, MD, USA) Immunofluorescent staining for microtubule-associated protein- 2 on neurons and glial fibrillary acidic protein in astrocytes showed that cultures were > 98% neurons; the remainder...
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Báo cáo khoa học: A hydrophilic cation-binding protein of Arabidopsis thaliana, AtPCaP1, is localized to plasma membrane via N-myristoylation and interacts with calmodulin and the phosphatidylinositol phosphates PtdIns(3,4,5)P3 and PtdIns(3,5)P2 pptx
... polypeptide For example, some a-subunits of G -protein heterotrimers, some small G-proteins and several non-receptor-type tyrosine kinases are N-myristoylated proteins Proteins with lipid modifications come ... peripheral membrane proteins, which are associated with membrane intrinsic proteins, and a mild detergent Triton X-100 is used to solubilize membrane proteins, but not all membrane integral proteins Partial ... function and intracellular localization of proteins [8–11] Very recently, a novel hydrophilic cation-binding protein was identified in Arabidopsis thaliana [12] The protein is composed of 225 amino acid...
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Báo cáo khoa học: Total chemical synthesis and NMR characterization of the glycopeptide tx5a, a heavily post-translationally modified conotoxin, reveals that the glycan structure is a-D-Gal-(1fi3)-a-D-GalNAc pot
... presynaptic Ca2+ channels or that it might act on these channels via other mechanisms, such as through G -protein- coupled presynaptic receptors [9] The composition of the O-glycan on the threonine residue ... (1991) Direct identification of gamma-carboxyglutamic acid in the sequencing of vitamin K-dependent proteins Anal Biochem 199, 93–97 13 Nakamura, T., Yu, Z.G., Fainzilber, M & Burlingame, A.L (1996) ... cysteine-rich peptide toxin with gamma-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile Protein Sci 5, 524–530 14 Wishart, D.S & Sykes, B.D (1994) Chemical Shifts as a Tool for Structure...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... family is composed of three proteins, ankyrin repeat domain-containing protein (Ankrd2), cardiac ankyrin repeat protein (CARP) and diabetes-related ankyrin repeat protein (DARP), grouped together ... majority of the substrates identified are structural proteins [3–5], proteins involved in cell metabolism [5–7] and in the regulation of gene and protein expression [2,7–9] were also suggested to ... Bradford technique (Bio-Rad, Hercules, CA, USA) The protein ⁄ DNA assays were carried out on 25 lg of total nuclear proteins using the TranSignal Protein ⁄ DNA Combo Array (Affymetrix, Santa Clara,...
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